Consider this:
Knowledge is material, “real” in the sense of it’s possession of concrete, definitive matter.
I look at my bicycle. There comes the image of this particular machine and then the memories of all of my experiences with this idea. This is followed by the sensations and emotions connected with this image.
There comes, also, the responses and reactions to the interaction with this idea; my mind communicates with my body the idea of the bicycle. My body then responds, whether positively or otherwise, to the introduction of specific chemicals via the brain.
Can it be assumed then, based upon the preceding statements, that one must be prepared, consciously, to take in new knowledge? Can it be said that it is all of one’s prior experiences with knowledge that prevents the introduction of new knowledge? Is it physical, mental, and emotional conditioning that is required for the understanding of new knowledge?